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The Lions kick off their three-match overseas tour in Canberra where they face the Brumbies in the GIO Stadium.
Brumbies scrumhalf Joe Powell will play his 50th Super Rugby match for the franchise when they host a Lions team looking to return to the top of the South African conference.
The Lions were bumped off the top with a thud when the Sharks mauled them 42-5 at Ellis Park last Friday.
The Brumbies are some way adrift of the Rebels who top the Aussie conference which has been as unpredictable as the SA section. They have every chance of hauling in the Rebels or at least securing one of the other playoff spots.
Lions Centre Lionel Mapoe also celebrates a milestone this weekend, he plays his 100th Super Rugby match for the Lions.
LIVE: Brumbies vs Lions
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15 Tom Banks, 14 Henry Speight, 13 Tevita Kuridrani, 12 Tom Wright, 11 Toni Pulu, 10 Christian Lealiifano, 9 Joe Powell, 8 Lachlan McCaffrey, 7 Tom Cusack, 6 Pete Samu, 5 Sam Carter, 4 Rory Arnold, 3 Allan Alaalatoa, 2 Folau Fainga’a, 1 Scott Sio
Substitutes: 16 Josh Mann-Rea, 17 James Slipper, 18 Leslie Leulua’iali’i-Makin, 19 Darcy Swain, 20 Jahrome Brown, 21 Matt Lucas, 22 Irae Simone, 23 Andy Muirhead
15 Andries Coetzee, 14 Ruan Combrinck, 13 Lionel Mapoe, 12 Franco Naude, 11 Aphiwe Dyantyi, 10 Elton Jantjies, 9 Nic Groom, 8 Hacjivah Dayimani, 7 Stephan Lewies, 6 Cyle Brink, 5 Marvin Orie, 4 Rhyno Herbst, 3 Johannes Jonker, 2 Malcolm Marx, 1 Nathan McBeth
Substitutes: 16 Robbie Coetzee, 17 Sti Sithole, 18 Carlu Sadie, 19 Wilhelm van der Sluys, 20 Marnus Schoeman, 21 Ross Cronje, 22 Gianni Lombard, 23 Sylvian Mahuza